Webin HepG2 cells, and reduced the protein levels of Connective Tissue Growth Factor (CTGF), Amphiregulin (AREG), and Survivin, thus inhibiting the proliferation of HepG2 cells and promoting apoptosis [15]. Recent studies [16-18] have shown that abnormalities in the Hippo pathway were closely related to WebNov 1, 2024 · YAP1, CTGF, AREG, and GLI2 were all over expressed in the tumor tissues of the model group (Fig. 8 b-f), which were consistent with the reports. Compared with the model group, the expression levels of these four proteins were significantly down-regulated in the PEO nanoemulsion treatment groups and free-PEO treatment group ( *** p < 0.001).
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WebJun 1, 2024 · Also, CTGF induced Glut3 (also known as SLC2A3) expression, leading to increased glycolysis, which enhanced cell proliferation and migration in tamoxifen … WebApr 21, 2024 · Our findings suggest that AREG neutralizing antibody antibodies combined with regorafenib can reverse the CCA metastatic phenotype and EMT in vitro and in vivo. ... including UHRF1, CTGF, SNAI2 ...
WebApr 4, 2024 · The mRNA expression levels of CTGF, AREG, and yap in the p-EGFP-MST1+DDP group decreased to about 0.2 times those in the control group, and showed statistical significance when compared with the p-EGFP-MST1 group (P < 0.05) and the DDP group (P < 0.05). These results indicate that the overexpression of MST1 can … WebThe mRNA expression levels of CTGF, AREG, and yap in the p-EGFP-MST1 group decreased to 0.2, 0.6, and 0.4 times those in the control group, respectively, and showed …
Webof an AREG-promoter fragment (Fig. 2d), comparable to that observed for the promoter of CTGF, a known YAP target gene9,14. Given the identification of AREG as a transcriptional target of YAP, we undertook a series of experiments to test the functional consequences of this interaction. We first tested whether neutralizing antibodies against AREG WebAug 9, 2013 · In addition, CTGF, AREG and Survivin have been identified as potential transcriptional targets of YAP required for cell growth and phenotypes. 10, 26, 28, 29, 30 Our previous study has found that ...
WebApr 13, 2024 · The identification of tissue-specific promoters for gene therapeutic constructs is one of the aims of complex tumor therapy. The genes encoding the fibroblast …
WebNov 1, 2024 · Remarkably, HN6 cells showed lower pYAP level and higher expression of YAP-regulated genes CTGF, CYR61, and AMOTL2, and the CTGF and CYR61 protein products ... FOSL1, EGR1, HMGA2, AREG, ... hike bruce trailWebApr 1, 2014 · Amphiregulin (AREG) is a ligand of the epidermal growth factor receptor (EGFR), a widely expressed transmembrane tyrosine kinase. ... Moreover, AREG treatment promotes the expression of connective tissue growth factor (CTGF), a potent fibrogenic mediator [139], both in liver fibrogenic cells and in hepatocytes [34], [140]. hike calculator percentageWebNov 22, 2009 · Connective tissue growth factor (CTGF) has been recently identified as a transcriptional target of YAP together with the transcription factor TEAD, and they … small victory speech gw2WebJan 21, 2016 · CTGF, Cyr61, Myc, AREG and AXL are the downstream targets of YAP and TAZ by interaction with TEADs. vgll directly regulates the expression of IGFBP-5, VEGFA and IRF2BP2 through TEADs. In colon ... small victory faith no moreWebJun 16, 2024 · Target genes of the YAP/TAZ-TEAD complex are genes such as CYR61, CTGF, AREG, VIM [13, 17,18,19]. ... Potter RL, Grotendorst GR (1991) Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol … hike by winnebagoWeb豆丁网是面向全球的中文社会化阅读分享平台，拥有商业,教育,研究报告,行业资料,学术论文,认证考试,星座,心理学等数亿实用 ... small victory granvilleWebCYR61 and CTGF belong to a family of secreted cysteine-rich proteins that regulate a plethora of biological processes, including cell migration, ... Amphiregulin (AREG) is a glycoprotein that can bind and activate the epidermal growth factor receptor (EGFR). small victory song